29. January 2018

Science Compact: Review summarizes scientific evidence and clinical results on CURODONT™ REPAIR

Over 40 scientific publications related to CURODONT™ REPAIR and the CUROLOX® TECHNOLOGY describe the development, function, safety and clinical efficacy of Guided Enamel Regeneration with the self-assembling peptide P11-4.

In their review article Alkilzy et al. summarize the knowledge and thorough development of this biomimetic technique. They describe how the self-assembling peptide P11-4 was designed to deliver a scaffold for improved (re)mineralization of the carious lesion body by an rational design of the self-assembling peptide to exhibit Ca2+-binding sites which correspond exactly to the spacing of the columnar Ca2+ ions in the hydroxyapatite crystal lattice. This explains the high affinity to hydroxyapatite and the potential to nucleate hydroxyapatite.

The researchers give an overview of several ex-vivo studies which demonstrate the retention of P11-4 in enamel, plus the formation of de novo minerals and additional mineral deposits compared to the gold standard of fluorides.

With the appraisal of the clinical studies the researcher from the Department of Preventive and Pediatric Dentistry at the University of Greifswald (Germany) conclude that:

“The results demonstrated that biomimetic mineralization facilitated by CURODONT® REPAIR (self-assembling peptide P11-4) in combination with fluoride is a simple, safe, and effective noninvasive treatment for early carious lesions, and is superior to the present clinical gold standard of fluoride treatment alone.”

The review was published in the “Advances in Dental Research 2018, Vol29(I) 42-47” in conjunction with ICNARA 3, a conference on new treatment concepts for caries which, was organized by John Featherstone, Mark Wolff and Margherita Fontana.


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