Literature
More than 20 years of dedicated research! The CUROLOX® TECHNOLOGY has been investigated in depth at various universities. Ranging from mode-of-action in-vitro studies up to gold-standard randomised controlled in-vivo studies. Many aspects of the unique CUROLOX® TECHNOLOGY have been explored- and there is many more to come!
Reference lists for all products with CUROLOX® TECHNOLOGY as well as for products of our license partner vVardis are available as PDF:
CUROLOX – vVardis
Aggeli, Alkilzy, Araujo, Ardu
Aggeli, A., M. Bell, et al. (1997)
«Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes.» Nature 386(6622): 259-262.
Aggeli, A., M. Bell, et al. (2003)
«pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.» J Am Chem Soc 125(32): 9619-9628.
Aggeli, A., N. Boden, et al. (2001)
«Self-assembling peptide systems in biology, medicine, and engineering.» Dordrecht ; Boston, Kluwer Academic Publishers.
Aggeli, A., I. A. Nyrkova, et al. (2001)
«Hierarchical self-assembly of chiral rod-like molecules as a model for peptide beta -sheet tapes, ribbons, fibrils, and fibers.» Proc Natl Acad Sci U S A 98(21): 11857-11862.
Alkilzy, M., Santamaria, R.M. et al., (2018)
«Treatment of Carious Lesions Using Self-Assembling Peptides» Adv Dent Res (2018), Vol. 29(1) 42–47
Alkilzy, M., Splieth, CH., et al (2018)
«Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel» J Dent Res (2018), 97(2) 148-154
Araujo, I.J. et al. (2019)
«P11-4 self-assembly peptide induces biomineralization without cytotoxicity in MDPC-23 cell line» Pulp Biology and Regeneration Group Satellite Meeting, Portland OR, USA 23-25 June 2019
Ardu, S. et al (2018)
«Protection Against Discolouration by Two Over-the Counter Desensitising Products» Oral Health Prev Dent 16(5) 439-444
Barbosa, Bell, Bommer, Bröseler, Brigi, Brubaker, Brunton
Barbosa-Martins, L. F., (2018)
«Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents.» J Mech Behaviour Beiomedical Materials https://doi.org/10.1016/j.jmbbm.2018.03.007
Barbosa-Martins, L.F. et al (2018)
«Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin.» Materials Sep 14;11(9): pii: E1733. doi: 10.3390/ma11091733
Bell, C. J., L. M. Carrick, et al. (2006)
«Self-assembling peptides as injectable lubricants for osteoarthritis.» J Biomed Mater Res A 78(2): 236-246.
Bommer, C. et al (2018)
“Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening” J Clin Dent 2018;29:57–63
Bröseler, F., Tietmann, C. et al. (2019)
«Randomised clinical trial investigating self assembling peptide P11-4 in the treatment of early caries.» Clin Oral Invest (2019): https://doi.org/10.1007/s00784-019-02901-4
Brigi, C. (2014)
«In vitro measurement of dental remineralisation: investigating a biomimetic self-assembling peptide treatment strategy» Master Thesis, Queen Mary, University of London.
Brubaker, L. et al. (2016)
«Remineralization of Early-Enamel lesions Using Biomimetic Regeneration Combined With Fluoride-toothpaste», AADR Los Angeles
Brunton, P.A., R. P. W. Davies, et al. (2013)
«Treatment of early caries lesions using biomimetic self-assembling-peptides – a clinical safety trial.» Brit Dent J: 215, E6, doi:10.1038/sj.bdj.2013.741.
Brunton P.A., R.P.W. Davies et al. (2012)
«Self-assembling peptides to support remineralisation of Tooth lesions – a biomimetic apprach.» ICNARA2, Chile.
Ceci, Chen
Ceci, M. et al (2015)
«Effect of self-assembling peptide P -4 on enamel erosion: AFM and SEM studies» Scanning
Chen X. et al, (2014)
«In vitro Evaluation of Dentine Remineralisation by a Self-Assembling Peptide Using Scanning Electron Microscopy. Abstract 40» Caries Res (48): (2014) 402
Chen X. et al, (2014)
«Dentine Tubule Occlusion of a Novel Self-assembling Peptide Containing Gel» (2014) IADR, Cape Town
Davies, de Sousa, Doberdoli
Davies, R. P. W., A. Aggeli, et al. (2009)
«Mechanisms and Principles of 1D Self-Assembly of Peptides into [beta]-Sheet Tapes.» Advances in Chemical Engineering. J. K. Rudy, Academic Press. Volume 35: 11-43.
Davies, R.P.W. et al (2014)
«Novel Self-Assembling Peptides, for the Treatment of Early Caries Lesions» Caries Res (48): (2014) 404
Davies, R.P.W. et al (2015)
«Treatment of Fabricated Caries Lesions; Self-assembling Peptides vs. Fluoride» Caries Res (49): (2015) 359
De Sousa, J.P. et al. (2018)
«The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin» J Dent Res doi.org/10.1177/00220345188173
Doberdoli, D., et al (2019)
«Efficacy of Self-assembling Peptide P11-4 with Fluoride Varnish or Self-assembling Peptide Matrix for the Treatment of Early Occlusal Carious Lesions” Oral Presentation 0368 at IADR 2019, Vancouver, Canada
Expert Round Table
Expert Round Table (2015)
«Biologische Schmelzregeneration ist Guided Enamel Regeneration» Dental Journal CH (02/15): 60
Felton
Felton, S. (2005)
«Self Assembling b-sheet Peptide Networks as Smart Scaffolds for Tissue Engineering.» Chemistry. Leeds, University of Leeds. PhD: 184.
Godenzi
Godenzi, D. (2018)
“Give Teeth a Chance: Curodont Repair in daily practice” Lecture at EAPD, Lugano Switzerland
Hug
Hug, M. (2013)
«Biomimetic Mineralization – Novel Strategies for Hard Tissue Regeneration in Dentistry.» Swiss Nano Convention. Congress Center Basel: 18
Jablonski-Momeni
Jablonski-Momeni, A. Heinzel-Gutenbrunner, M.(2014)
«Efficacy of the self-assembling peptide P11-4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces» J Orofac Orthop May;75(3):175-90.
Jablonski-Momeni, A., et al. (2019)
«Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions» Scientific Reports volume 9, Article number: 269
Jablonski-Momeni, A., et al. (2020)
«Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets» Sci Rep 10, 15132 (2020)
Kamal, Kind, Kirkham, Knaup, Koch, Kunzelmann, Kyle
Kamal, D. et al (2018)
«Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An in vitro study» J Conserv Dent 2018;21:536-41
Kamal, D., et al (2017)
«Comparative Evaluation of Remineralizing Efficacy of Biomimetic Self-Assembling Peptide on Artificially Induced Enamel Lesions» Caries Res 51: 359, DOI: 10.1159/000471777
Kind, L., A. Wuethrich, et al. (2013)
«A self-assembling peptide with the potential of non-invasive regeneration of early caries lesion.» Clin Oral Investig 17(3)
Kind, L. et al (2017)
«Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide.» J Dent Res (Online First), DOI: 10.1177/0022034517698419
Kirkham, J. (2013)
«Filling without Drilling: A Biomimetic approach to dental tissue regeneration and repair.» British Society of Restorative Dentistry Spring Meeting, Manchester
Kirkham, J., A. Firth, et al. (2007)
«Self-assembling peptide scaffolds promote enamel remineralization.» J Dent Res 86(5): 426-430.
Knaup, T., et al (2020)
«Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets.» J Orofac Orthop https://doi.org/10.1007/s00056-020-00247-1
Koch, F., et al (2018)
«Mechanical characteristics of beta sheet forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition» R.Soc Open Sci 5: 171562
Koch, F., et al (2018)
«Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro» Int J Nanomedicine 2018:13 doi.org/10.2147/IJN.S173702
Koch, F., et al (2019)
«A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential» Adv Healthc Mater 2019: e1900167 doi.org/10.1002/adhm.201900167
Koch, F. et al (2020)
«Development and application of a 3D periodontal in vitro model for the evaluation of fibrillar biomaterials.” BMC Oral Health doi.org/10.1186/s12903-020-01124-4
Kunzelmann, K.-H. et al. (2015)
«Working Mechanism of Tooth Whitening Based on Hydroxyapatite Suspended in a P11-4 Peptide Matrix», IADR, Boston
Kyle, S., A. Aggeli, et al. (2010)
«Recombinant self-assembling peptides as biomaterials for tissue engineering.» Biomaterials 31(36): 9395-9405.
Kyle, S., A. Aggeli, et al. (2008)
«The self assembling peptide, P11-4 for a scaffold in regenerative medicine.» Eur Cell and Materials 16(Suppl 3): 70
Kyle, S. (2010)
«Self-assembling peptides as scaffolds for tissue engineering.» Biological Sciences. Leeds, The University of Leeds. PhD: 360.
Lysek
Lysek, D.A. et al (2016)
«Randomised Clinical Trial Evaluating a Novel Dentine Hypersensitivity Relieve Gel», AADR Los Angeles.
Mannaa, Maude, Meyer, Müller
Mannaa, A., Krejci, I., et al. (2018)
«RCT Investigating the Efficacy of Self-Assembling Peptide for Early Caries»
Oral presentaion 0456 at the IDAR 2018 in London
Maude, S., D. E. Miles, et al. (2011)
«De novo designed positively charged tape-forming peptides: self-assembly and gelation in physiological solutions and their evaluation as 3D matrices for cell growth.» Soft Matter 7(18): 8085-8099.
Maude, S., L. R. Tai, et al. (2012)
«Peptide synthesis and self-assembly.» Top Curr Chem 310: 27-69.
Meyer, N. et al. (2016)
«In vitro periodontal ligament model to assess synthetic self- assembling peptides for regeneration.» BioInterfaces 2016, Zürich.
Meyer, N. et al. (2017)
«Three dimensional model of the human periodontal ligament to be used as a middle-throughput test system.» European Cells and Materials Vol. 33 Suppl. 2, 2017 (P313)
Müller, P. et al. (2013)
«Evaluation of a tooth gel with Curolox® Technology as part of professional tooth-cleaning, with regards to patient satisfaction and the effects of hypersensitivity» (2013) Swiss Dental Hygienists Conference, Lausanne.
Patel, Philip, Porta, Ratzmann
Patel, S. et al (2016)
«In Vitro Assessment of a Novel Biomimetic-Regeneration of Early Caries Lesions», AADR Los Angeles
Porta, F., L. Kind, et al. (2013)
«In vitro Models for P11-4 Detection in Dental White Spots.» Swiss Nanoconvention 2013. Basel
Philip, N. (2018)
«State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management.» Caries Res 53: 284-295
Ratzmann, A. et al (2018).
«Evaluation von “Curodont Repair” in der Initialkariestherapie nach Mulitbracketbehandlung.» P18, 91. Jahresdatung der DGKFO, Bremen, Germany.
Saha, Savas, Scanlon, Schlee, Schmidlin, Sedlakova, Silvertown, Soares, Stevanovic
Saha, S., et al. (2019)
«A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study» Bone 24 (127):602-611. doi:10.1016/j.bone.2019.06.020
Savas, S. et al (2016)
«Effects of Remineralization Agents on Artificial Carious Lesions» Pediatric Dentistry, Volume 38, Number 7, November 2016, pp. 511-518(8)
Scanlon, S., A. Aggeli, et al. (2009)
«Organisation of self-assembling peptide nanostructures into macroscopically ordered lamella-like layers by ice crystallisation.» Soft Matter 5: 1237-1247
Schlee, M., et al (2017)
«Clinical performance of self-assembling peptide P11-4 in the treatment of initial proximal carious lesions: A practice-based case series» J Invest Clin Dent. 2017;e12286.
Schlee, M., et al (2014)
«Clinical effect of biomimetic mineralization in approximal caries. Results of a clinical study after 6 months.» Stomatologie 111(2014): 175-181.
Schmidlin, P. et al (2016)
«In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides.» J Appl Oral Sci 24(1), 31-6.
Sedlakova Kondelova, P., et al (2020)
«Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial.»
Sci Rep 10, 20211 (2020).
Silvertown, J. et al (2017)
«Remineralization of natural early caries lesions in vitro by P11-4 monitored with photothermal radiometry and luminescence.» J Invest Clin Dent 00:e12257.doi:10.1111/jicd.12257.
Soares, R. et al (2017)
«Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study» J Clin Diagn Res Vol-11(4): ZC136-ZC141
Stevanovic, S., L. Kind, et al. (2013)
«Bioceramic tooth model to study caries.» Clin Oral Investig 17(3)
«Application of the Self- Assembling Peptide P11-4 for Prevention of Acidic Erosion» Operative Dentistry; In-Press, doi: 10.2341/17-175-L
Takahashi, Thomson
Takahashi, F. et al. (2016)
«Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization.» Acta Odontol Scand (74):(2016) 142-7.
Takahashi, H. et al (2016)
«Evaluation of Application of Peptide P11-4 on Remineralization of Enamel.» AADR Los Angeles.
Thomson, B.M. et al, (2014)
«P11-15 (NNRFEWEFENN): A biocompatible, self-assembling peptide with potential to promote enamel remineralisation. Abstract 47» Caries Res (48): (2014) 411
Üstün, Welk, Wilshaw
Üstün, N., et a.l (2019)
«Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions.» Microsc Res Tech DOI: 10.1002/jemt.23254.
Welk, A. et al (2020)
«Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions.» Scientific Rep doi.org/10.1038/s41598-020-63633-0
Wilshaw, S. P., A. Aggeli, et al. (2008)
«In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications.» Eur Cell and Materials 16(Suppl 3): 97.