Using the intrinsic properties of the peptide
Intelligently designed peptides have the ability to form three-dimensional fibre-networks or matrices. These matrices can be used for biological processes such as mineralisation of enamel. That is what scientists from the University of Leeds, UK, have shown for P11-4 – the main component of CURODONT™ – in various in vitro studies and a clinical trial.
Additional clinical studies are presently conducted investigating the efficacy of the technology in various dental indications.
References
- Aggeli, A., M. Bell, et al. (1997). "Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes." Nature 386(6622): 259-262.
- Aggeli, A., M. Bell, et al. (2003). "pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases." J Am Chem Soc 125(32): 9619-9628.
- Aggeli, A., N. Boden, et al. (2001). Self-assembling peptide systems in biology, medicine, and engineering. Dordrecht ; Boston, Kluwer Academic Publishers.
- Aggeli, A., I. A. Nyrkova, et al. (2001). "Hierarchical self-assembly of chiral rod-like molecules as a model for peptide beta -sheet tapes, ribbons, fibrils, and fibers." Proc Natl Acad Sci U S A 98(21): 11857-11862.
- Bell, C. J., L. M. Carrick, et al. (2006). "Self-assembling peptides as injectable lubricants for osteoarthritis." J Biomed Mater Res A 78(2): 236-246.
- Brunton P.A., R.P.W. Davies et al. (2012). Self-assembling peptides to support remineralisation of Tooth lesions - a biomimetic apprach. ICNARA2, Chile.
- Davies, R. P. W., A. Aggeli, et al. (2009). Mechanisms and Principles of 1D Self-Assembly of Peptides into [beta]-Sheet Tapes. Advances in Chemical Engineering. J. K. Rudy, Academic Press. Volume 35: 11-43.
- Felton, S. (2005). Self Assembling b-sheet Peptide Networks as Smart Scaffolds for Tissue Engineering. Chemistry. Leeds, University of Leeds. PhD: 184.
- Kirkham, J., A. Firth, et al. (2007). "Self-assembling peptide scaffolds promote enamel remineralization." J Dent Res 86(5): 426-430.
- Kyle, S., A. Aggeli, et al. (2010). "Recombinant self-assembling peptides as biomaterials for tissue engineering." Biomaterials 31(36): 9395-9405.
- Kyle, S., A. Aggeli, et al. (2008). "The self assembling peptide, P11-4 for a scaffold in regenerative medicine." Eur Cell and Materials 16(Suppl 3): 70
- Kyle, S. (2010). Self-assembling peptides as scaffolds for tissue engineering. Biological Sciences. Leeds, The University of Leeds. PhD: 360.
- Maude, S., D. E. Miles, et al. (2011). "De novo designed positively charged tape-forming peptides: self-assembly and gelation in physiological solutions and their evaluation as 3D matrices for cell growth." Soft Matter 7(18): 8085-8099.
- Maude, S., L. R. Tai, et al. (2012). "Peptide synthesis and self-assembly." Top Curr Chem 310: 27-69.
- Scanlon, S., A. Aggeli, et al. (2009). "Organisation of self-assembling peptide nanostructures into macroscopically ordered lamella-like layers by ice crystallisation." Soft Matter 5: 1237-1247
- Wilshaw, S. P., A. Aggeli, et al. (2008). "In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications." Eur Cell and Materials 16(Suppl 3): 97.

- White spot before treatment

- White spot after treatment
